Outcomes

What were the main findings from the studies?

MICARDIS^® 80 mg once daily consistently showed superior reduction in blood pressure in the last 6 hours of the dosing interval compared with ramipril 10 mg in both studies.^2,3
MICARDIS^® significantly reduced 24-hour mean, morning, daytime and night-time blood pressure compared with ramipril 10 mg.^2,3
MICARDIS^® was well tolerated, with a lower incidence of cough than seen with ramipril.^2,3

MICARDIS^® was more effective than ramipril at reducing blood pressure in the last 6 hours of the dosing interval

MICARDIS^® was more effective than ramipril at reducing blood pressure in the last 6 hours of the dosing interval

MICARDIS^® was consistently more effective than ramipril at reducing DBP during the morning, daytime, and at night

MICARDIS^® was consistently more effective than ramipril at reducing DBP during the morning, daytime, and at night

Both treatments were well tolerated - most adverse events were of mild or moderate intensity. Slightly more patients discontinued ramipril due to adverse events. Incidence of cough was markedly greater with ramipril than with MICARDIS^®